| Skuespillere |
| Tobey Maguire |
Spider-Man / Peter Parker
|
| Kirsten Dunst |
Mary Jane Watson
|
| James Franco |
New Goblin / Harry Osborn
|
| Thomas Haden Church |
Sandman / Flint Marko
|
| Topher Grace |
Venom / Eddie Brock
|
| Bryce Dallas Howard |
Gwen Stacy
|
| Rosemary Harris |
May Parker
|
| J.K. Simmons |
J. Jonah Jameson
|
| James Cromwell |
Captain Stacy
|
| Theresa Russell |
Emma Marko
|
|
| Medarbeidere |
| Regissør |
Sam Raimi |
| Forfatter |
Sam Raimi |
| Forfatter |
Ivan Raimi |
| Produsent |
Avi Arad |
| Produsent |
Joseph M. Caracciolo |
|
